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Article

Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors

31 Aug 2018

Abstract excerpt

Abstract Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great promise for understanding the biological underpinnings of disease and advancing therapeutic precision medicine. Despite the increased use of organoids, the fidelity of molecular features, genetic heterogeneity, and drug response to the tumor of origin remain important unanswered questions limiting their utility. To...

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PMID: 30171177
DOI: 10.1158/1541-7786.mcr-18-0531

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