Article

Reconstructing cell interactions and state trajectories in pancreatic cancer stromal tumoroids

2022-02-16

Abstract excerpt

Interlineage communication within a cancer microenvironment can augment cancer cell behaviour and impact response to therapy. Patient-derived cancer organoids provide an opportunity to explore cancer cell biology, however it is a major challenge to generate a complex cancer microenvironment in vitro. Here, we established a stromal tumoroid culture system modeling pancreatic ductal adenocarcinoma (PDAC) that recons...

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Literature Corpus work: a0f28b2d-8049-5d4b-b03d-4384cff56391
DOI: 10.1101/2022.02.14.480334

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