Article

Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1

2023-02-16

Abstract excerpt

<title>Abstract</title> <p>ER aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that excises N-terminal residues off peptides that then bind onto Major Histocompatibility Complex I molecules (MHC-I) and indirectly modulates adaptive immune responses. ERAP1 contains an allosteric regulatory site that accommodates the C-terminus of at least some peptide substrates, raising questions about its exact influenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff99b3cb-48b9-567c-9768-eab20097a9f5
DOI: 10.21203/rs.3.rs-2585686/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1DOI 10.21203/rs.3.rs-2585686/v1Read

Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1Semantic proximity Read

ERAP1 activity modulates the immunopeptidome but also affects the proteome, metabolism and stress responses in cancer cellsSemantic proximity Read

Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application.Semantic proximity Read

ERAP1: a potential therapeutic target for a myriad of diseasesSemantic proximity Read

Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.Semantic proximity Read

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.Semantic proximity Read

ERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytesSemantic proximity Read

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.Semantic proximity Read

Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.Semantic proximity Read

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic propertiesSemantic proximity Read

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.Semantic proximity Read

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.Semantic proximity Read