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Article

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Biochemistry - 14 Mar 2017

Stamogiannos Athanasios, Maben Zachary, Papakyriakou Athanasios, Mpakali Anastasia, Kokkala Paraskevi, Georgiadis Dimitris, Stern Lawrence J, Stratikos Efstratios

Abstract excerpt

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that is important for the generation of antigenic epitopes and major histocompatibility class I-restricted adaptive immune responses. ERAP1 processes a vast variety of different peptides but still shows length and sequence selectivity, although the mechanism behind these properties is poorly understood. X-ray crystallographic analysis has...

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Identifiers

PMID: 28218509
DOI: 10.1021/acs.biochem.6b01170
PMCID: PMC6374128

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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