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Article

Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application.

Current medicinal chemistry - 1 Jan 2019

Georgiadis Dimitris, Mpakali Anastasia, Koumantou Despoina, Stratikos Efstratios

Abstract excerpt

Endoplasmic Reticulum aminopeptidase 1 and 2 are two homologous enzymes that help generate peptide ligands for presentation by Major Histocompatibility Class I molecules. Their enzymatic activity influences the antigenic peptide repertoire and indirectly controls adaptive immune responses. Accumulating evidence suggests that these two enzymes are tractable targets for the regulation of immune responses with...

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Topics

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Share to Aminopeptidases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29446724
DOI: 10.2174/0929867325666180214111849

Genes

ERAP1
ERAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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