Article

ERAP1 activity modulates the immunopeptidome but also affects the proteome, metabolism and stress responses in cancer cells

2024-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes the peptide repertoire available for binding to Major Histocompatibility Complex Class I molecules (MHC-I). Moreover, it may have additional effects on cellular homeostasis, which have not been explored. To address these questions, we used both genetic silencing of ERAP1 expression as well as treatm...

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Literature Corpus work: 2872cfe3-656c-5268-840b-9b3e9630ed1d
DOI: 10.1101/2024.09.20.613815

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