Article

FcyRIIB is a novel immune checkpoint in the tumor microenvironment limiting activity of Treg-targeting antibodies

2023-01-20

Abstract excerpt

<h4>Summary</h4> Despite pre-clinical murine data supporting T regulatory (Treg) cell depletion as a major mechanism by which anti-CTLA-4 antibodies function in vivo, the two main antibodies tested in patients (ipilimumab and tremelimumab) have failed to demonstrate similar effects. We report analogous findings in an immunocompetent murine model humanized for CTLA-4 and Fcy receptors (hCTLA-4/hFcyR mice), where b...

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Literature Corpus work: ff5d7731-dcf0-5c1f-b285-bfe603f6de91
DOI: 10.1101/2023.01.19.522856

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