Article
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Cancer cell - 9 Apr 2018
Arce Vargas Frederick, Furness Andrew J S, Litchfield Kevin, Joshi Kroopa, Rosenthal Rachel, Ghorani Ehsan, Solomon Isabelle, Lesko Marta H, Ruef Nora, Roddie Claire, Henry Jake Y, Spain Lavinia, Ben Aissa Assma, Georgiou Andrew, Wong Yien Ning Sophia, Smith Myles, Strauss Dirk, Hayes Andrew, Nicol David, O'Brien Tim, Mårtensson Linda, Ljungars Anne, Teige Ingrid, Frendéus Björn, Pule Martin, Marafioti Teresa, Gore Martin, Larkin James, Turajlic Samra, Swanton Charles, Peggs Karl S, Quezada Sergio A
Abstract excerpt
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with...
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