Article
Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.
mAbs - 1 Oct 2017
Zhang Di, Armstrong Anthony A, Tam Susan H, McCarthy Stephen G, Luo Jinquan, Gilliland Gary L, Chiu Mark L
Abstract excerpt
Immunostimulatory receptors belonging to the tumor necrosis factor receptor (TNFR) superfamily are emerging as promising targets for cancer immunotherapies. To optimize the agonism of therapeutic antibodies to these receptors, Fc engineering of antibodies was applied to facilitate the clustering of cell surface TNFRs to activate downstream signaling pathways. One engineering strategy is to identify Fc mutations...
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