Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy.

doi:10.1136/jitc-2020-001749

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Article

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy.

Journal for immunotherapy of cancer - 1 Feb 2021

Van Damme Helena, Dombrecht Bruno, Kiss Máté, Roose Heleen, Allen Elizabeth, Van Overmeire Eva, Kancheva Daliya, Martens Liesbet, Murgaski Aleksandar, Bardet Pauline Madeleine Rachel, Blancke Gillian, Jans Maude, Bolli Evangelia, Martins Maria Solange, Elkrim Yvon, Dooley James, Boon Louis, Schwarze Julia Katharina, Tacke Frank, Movahedi Kiavash, Vandamme Niels, Neyns Bart, Ocak Sebahat, Scheyltjens Isabelle, Vereecke Lars, Nana Frank Aboubakar, Merchiers Pascal, Laoui Damya, Van Ginderachter Jo Agnes

Abstract excerpt

BACKGROUND: Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population, indicating the need for a ti-Treg specific biomarker. METHODS: We employed single-cell RNA-sequencing in a mouse model of non-small cell lung carcinoma (NSCLC) to...

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Identifiers

PMID: 33589525
DOI: 10.1136/jitc-2020-001749
PMCID: PMC7887378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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