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Article

High-throughput identification of protein turnover modulators in human neurons

2026-05-07

Abstract excerpt

Disturbances in protein homeostasis are a defining feature of aging and neurodegenerative diseases. However, current proteomics approaches do not enable screening-scale pharmacological interrogation of protein turnover in post-mitotic human neurons. Here we establish a Mammalian Cell-optimized Fluorescent Timer (MCFT)-based live-cell imaging platform to quantify global protein synthesis and degradation rates in hu...

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Literature Corpus work
3478c8c6-cbd5-576c-9ce7-3860f42dd197
DOI
10.64898/2026.05.06.723176
Open publication

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High-throughput identification of protein turnover modulators in human neuronsDOI 10.64898/2026.05.06.723176
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