Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.

Abstract excerpt

Neurodegenerative diseases are highly debilitating conditions characterised primarily by progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) is one of the most common of these disorders, affecting 1-2% of the population above the age of 65. Although the underlying mechanisms of PD have been extensively studied, we still lack a full understanding of the molecular underpinnings...

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• alpha-Synuclein
• Cell Line
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Nerve injury and regeneration