Article

Epistasis regulates genetic control of cardiac hypertrophy

2023-11-20

Abstract excerpt

<title>Abstract</title> <p>The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy. We derive deep learning-based estimates of left ventric...

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Literature Corpus work: ff4eaa75-964c-5fbe-bd1d-c2b09c43e867
DOI: 10.21203/rs.3.rs-3509208/v1

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