Article
New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping.
Circulation. Genomic and precision medicine - 1 Oct 2025
Lu Chang, McGurk Kathryn A, Zheng Sean L, de Marvao Antonio, Inglese Paolo, Bai Wenjia, Ware James S, O'Regan Declan P
Abstract excerpt
BACKGROUND: Cardiac remodeling occurs in the mature heart and is a cascade of adaptations in response to stress, which are primed in early life. A key question remains as to the processes that regulate the geometry and motion of the heart and how it adapts to stress. METHODS: We performed spatially resolved phenotyping using machine learning-based analysis of cardiac magnetic resonance imaging in 47 549 UK...
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