Article
Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy.
Nature communications - 30 Nov 2023
Ning Caibo, Fan Linyun, Jin Meng, Wang Wenji, Hu Zhiqiang, Cai Yimin, Chen Liangkai, Lu Zequn, Zhang Ming, Chen Can, Li Yanmin, Zhang Fuwei, Wang Wenzhuo, Liu Yizhuo, Chen Shuoni, Jiang Yuan, He Chunyi, Wang Zhuo, Chen Xu, Li Hanting, Li Gaoyuan, Ma Qianying, Geng Hui, Tian Wen, Zhang Heng, Liu Bo, Xia Qing, Yang Xiaojun, Liu Zhongchun, Li Bin, Zhu Ying, Li Xiangpan, Zhang Shaoting, Tian Jianbo, Miao Xiaoping
Abstract excerpt
Left ventricular regional wall thickness (LVRWT) is an independent predictor of morbidity and mortality in cardiovascular diseases (CVDs). To identify specific genetic influences on individual LVRWT, we established a novel deep learning algorithm to calculate 12 LVRWTs accurately in 42,194 individuals from the UK Biobank with cardiac magnetic resonance (CMR) imaging. Genome-wide association studies of CMR-derived...
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