Article
Epistasis regulates genetic control of cardiac hypertrophy.
Nature cardiovascular research - 1 Jun 2025
Wang Qianru, Tang Tiffany M, Youlton Michelle, Weldy Chad S, Kenney Ana M, Ronen Omer, Hughes J Weston, Chin Elizabeth T, Sutton Shirley C, Agarwal Abhineet, Li Xiao, Behr Merle, Kumbier Karl, Moravec Christine S, Tang W H Wilson, Margulies Kenneth B, Cappola Thomas P, Butte Atul J, Arnaout Rima, Brown James B, Priest James R, Parikh Victoria N, Yu Bin, Ashley Euan A
Abstract excerpt
Although genetic variant effects often interact nonadditively, strategies to uncover epistasis remain in their infancy. Here we develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy, using deep learning-derived left ventricular mass estimates from 29,661 UK Biobank cardiac magnetic resonance images. We report epistatic variants near CCDC141, IGF1R,...
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