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Obesity-instructed <i> TREM2 <sup>high</sup> </i> macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolution

2021-05-30

Abstract excerpt

Mouse models are a tool for studying the mechanisms underlying complex diseases; however, differences between species pose a significant challenge for translating findings to patients. Here, we used single-cell transcriptomics and orthogonal validation approaches to provide cross-species taxonomies, identifying shared broad cell classes and unique granular cellular states, between mouse and human kidney. We genera...

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Literature Corpus work
ff4e854a-4c54-5a6b-bab4-0adcb3ba544d
DOI
10.1101/2021.05.30.446342
Open publication

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Obesity-instructed <i> TREM2 <sup>high</sup> </i> macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolutionDOI 10.1101/2021.05.30.446342
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