Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity

Abstract excerpt

Obesity promotes diverse pathologies, including atherosclerosis and dementia, which frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has distinct EC subtypes, but whether ECs are differentially affected by obesity is unknown. Here we use single-cell RNA sequencing to analyze transcriptomes of ~375,000 ECs from seven organs in male mice at progressive stages of obesity to...

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• Adipose Tissue and Metabolism
• Birth, Development, and Health
• Single-cell and spatial transcriptomics