Article

Multi-organ single-cell RNA-sequencing reveals early hyperglycaemia responses that converge on fibroblast dysregulation

2023-08-07

Abstract excerpt

Diabetes causes a range of complications that can affect multiple organs. Hyperglycaemia is an important driver of diabetes-associated complications, mediated by biological processes such as dysfunction of endothelial cells, fibrosis and alterations in leukocyte number and function. Here, we dissected the transcriptional response of key cell types to hyperglycaemia across multiple tissues using single-cell RNA-seq...

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Literature Corpus work: c2ae70b3-f43c-59de-bafd-ac0df03359a1
DOI: 10.1101/2023.08.07.552307

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