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Elucidation of multiple high-resolution states of human MutSβ by cryo-EM reveals interplay between ATP/ADP binding and heteroduplex DNA recognition

2023-05-10

Abstract excerpt

Human and mouse genetic studies have demonstrated a role for DNA mismatch repair (MMR) molecular machines in modulating the rate of somatic expansion of the huntingtin ( HTT) CAG repeats, and onset and progression of Huntington’s Disease (HD). MutSβ, a key component of the MMR pathway, is a heterodimeric protein of MSH2 and MSH3 that recognizes and initiates the repair of extrahelical DNA extrusions. Loss-of-func...

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Literature Corpus work: ff2b0aeb-738b-5fa2-98d6-9ed03a1b53bf
DOI: 10.1101/2023.05.08.539930

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