Article

Interaction between histone residue H3K56 and mismatch repair protein MutSβ drives CAG repeat expansion

2024-09-29

Abstract excerpt

DNA repair protein MutSβ promotes CAG•CTG repeat expansions, which cause ∼20 untreatable neurodegenerative disorders including Huntington’s disease (HD). However, how MutSβ is recruited onto chromatin to enable repeat expansion is unknown. Here, we show that H3K56 interacts with MutSβ and brings it to chromatin. The H3K56-MutSβ interaction is regulated by H3K56 acetylation (H3K56ac) conditions, with acetylation in...

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Literature Corpus work: e9b5c130-dd4f-58d1-959b-2da49d9effb8
DOI: 10.1101/2024.09.29.615664

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