Article

Development of a cellular reporter assay to measure activity of MutSβ, a therapeutic target for Huntington’s disease

2023-09-09

Abstract excerpt

Genetic modifiers of age of onset in Huntington’s disease (HD) provide compelling evidence that somatic expansion of the CAG repeats is a critical driver of pathogenesis and demonstrate that repeat instability is modulated by DNA mismatch repair (MMR). A component of this pathway, MutSβ, a heterodimer comprised of MSH2 and MSH3, has emerged as a potential target for small-molecule therapeutic intervention. However...

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Literature Corpus work: 42225822-b41a-5ee1-b2db-bcd2fe6c7a5d
DOI: 10.1101/2023.09.07.555786

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