Article
Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.
Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Aug 2011
Tseng Quincy, Orans Jillian, Hast Michael A, Iyer Ravi R, Changela Anita, Modrich Paul L, Beese Lorena S
Abstract excerpt
MutSβ is a eukaryotic mismatch repair protein that preferentially targets extrahelical unpaired nucleotides and shares partial functional redundancy with MutSα (MSH2-MSH6). Although mismatch recognition by MutSα has been shown to involve a conserved Phe-X-Glu motif, little is known about the lesion-binding mechanism of MutSβ. Combined MSH3/MSH6 deficiency triggers a strong predisposition to cancer in mice and...
Topics
Join the communities discussing this publication.