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Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

3 Feb 2020

Abstract excerpt

MutL proteins are ubiquitous and play important roles in DNA metabolism. MutLγ (MLH1-MLH3 heterodimer) is a poorly understood member of the eukaryotic family of MutL proteins that has been implicated in triplet repeat expansion, but its action in this deleterious process has remained unknown. In humans, triplet repeat expansion is the molecular basis for ∼40 neurological disorders. In addition to MutLγ, triplet...

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PMID: 32015124
DOI: 10.1073/pnas.1914718117

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