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Article

Emerging Role of CREB in Epithelial to Mesenchymal Plasticity of Pancreatic Cancer

21 Jun 2022

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid malignancy with a high rate of metastasis and therapeutic resistance as its major hallmarks. Although a defining mutational event in pancreatic cancer initiation is the presence of oncogenic KRAS, more advanced PDAC lesions accumulate additional genomic alterations, including loss of tumor suppressor gene TP53. Co-occurrence of mutant KRAS and TP53 in...

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PMID: 35800049
DOI: 10.3389/fonc.2022.925687

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