Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells.

doi:10.1371/journal.pone.0238070

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Article

Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells.

PloS one - 1 Jan 2020

Sinha Sushmita, Renavikar Pranav S, Crawford Michael P, Steward-Tharp Scott M, Brate Ashley, Tsalikian Eva, Tansey Michael, Shivapour Ezzatollah T, Cho Tracey, Kamholz John, Karandikar Nitin J

Abstract excerpt

Factors regulating self-antigen directed immune-responses in autoimmunity are poorly understood. Signal regulatory protein gamma (SIRPγ) is a human T-cell specific protein with genetic variants associated with type 1 diabetes (T1D). SIRPγ's function in the immune system remains unclear. We show that T1D and relapsing remitting multiple sclerosis (RRMS) subjects have significantly greater frequency of rs2281808 T...

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Identifiers

PMID: 32853219
DOI: 10.1371/journal.pone.0238070
PMCID: PMC7451561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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