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Article

Genetic Control of Splicing at SIRPG Modulates Risk of Type 1 Diabetes.

Diabetes - 1 Feb 2022

Smith Morgan J, Pastor Lucia, Newman Jeremy R B, Concannon Patrick

Abstract excerpt

Signal regulatory protein SIRPγ (CD172G) is expressed on the surface of lymphocytes, where it acts by engaging its ligand, CD47. SIRPG, which encodes SIRPγ, contains a nonsynonymous coding variant, rs6043409, which is significantly associated with risk for type 1 diabetes. SIRPG produces multiple transcript isoforms via alternative splicing, all encoding potentially functional proteins. We show that rs6043409...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34799406
DOI: 10.2337/db21-0194
PMCID: PMC8914281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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