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Article

The blood coagulation system as a molecular machine.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Dec 2003

Spronk Henri M H, Govers-Riemslag José W P, ten Cate Hugo

Abstract excerpt

The human blood coagulation system comprises a series of linked glycoproteins that upon activation induce the generation of downstream enzymes ultimately forming fibrin. This process is primarily important to arrest bleeding (hemostasis). Hemostasis is a typical example of a molecular machine, where the assembly of substrates, enzymes, protein cofactors and calcium ions on a phospholipid surface markedly...

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Identifiers

PMID: 14635257
DOI: 10.1002/bies.10360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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