Article

Soluble LIGHT (TNFSF14) activates endothelial cells, thereby priming the first vessel-occlusive events in acute sickle cell disease

2023-06-08

Abstract excerpt

<h4>ABSTRACT</h4> In sickle cell disease (SCD), the red blood cells carry a mutated form of hemoglobin (HbS) leading to altered shape and deformability. The mutation causes abnormal hemorheological properties, mechanical hemolysis, and adhesion. The chronic vascular inflammation observed in SCD and hemolysis-related endothelium activation may trigger the vaso-occlusion of blood vessels. The prothrombotic and pro-...

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Literature Corpus work: c57e8295-2eab-53a1-a9d4-1337651910dd
DOI: 10.1101/2023.06.08.541088

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