Article
Elevated plasma levels and platelet-associated expression of the pro-thrombotic and pro-inflammatory protein, TNFSF14 (LIGHT), in sickle cell disease.
British journal of haematology - 1 Sept 2012
Garrido Vanessa T, Proença-Ferreira Renata, Dominical Venina M, Traina Fabiola, Bezerra Marcos A C, de Mello Mariana R B, Colella Marina P, Araújo Aderson S, Saad Sara T O, Costa Fernando F, Conran Nicola
Abstract excerpt
Chronic vascular inflammation and endothelial activation may initiate vaso-occlusion in sickle cell disease (SCD). TNFSF14 (CD258; LIGHT), a recently-identified pro-thrombotic and pro-inflammatory tumour necrosis factor (TNF)-superfamily cytokine, has a potent activating effect on endothelial cells. We evaluated whether TNFSF14 production is altered in SCD and whether platelets contribute to this production....
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