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Article

Role of the coagulation system in the pathogenesis of sickle cell disease

22 Oct 2019

Abstract excerpt

Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder affecting millions worldwide. SCD causes vascular occlusions, chronic hemolytic anemia, and cumulative organ damage such as nephropathy, pulmonary hypertension, pathologic heart remodeling, and liver necrosis. Coagulation system activation, a conspicuous feature of SCD that causes chronic inflammation, is an important component of SCD...

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PMID: 31648337
DOI: 10.1182/bloodadvances.2019000193

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