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TFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in Polycythemia

2023-09-18

Abstract excerpt

<title>Abstract</title> <p>Bleeding and thrombosis are known as common complications of polycythemia for a long time. However, the role of coagulation system in erythropoiesis is unclear. Here, we discover that an anticoagulant protein tissue factor pathway inhibitor (TFPI) plays an essential role in erythropoiesis via the control of heme biosynthesis in central macrophages. TFPI levels are elevated in erythrobla...

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Literature Corpus work
89673c6a-7d0e-587a-96ea-2b724063691a
DOI
10.21203/rs.3.rs-3202992/v1
Open publication

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TFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in PolycythemiaDOI 10.21203/rs.3.rs-3202992/v1
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