Article

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

2020-11-04

Abstract excerpt

<h4>Background</h4> Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little of the mechanisms that govern heterogeneity of tumor cells nor of the role heterogeneity plays in overcoming stresses, such as adaptation to different microenvironments. Osteosarcoma is an ideal model for studying these mechanisms—it exhibits widespread inter- and intra-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56979875-1331-52e7-af56-9055e71532b7
DOI: 10.1101/2020.11.03.367342

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonizationDOI 10.1101/2020.11.03.367342Read

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolutionSemantic proximity Read

Integrative Single-cell and Spatial Transcriptomic Analysis of Osteosarcoma Reveals Conserved and Distinct Ecosystems Across Sites and SpeciesSemantic proximity Read

Single-cell RNA sequencing reveals route-specific remodeling of the tumor microenvironment and identifies predictive factors of breast cancer metastasisSemantic proximity Read

Fluctuating environment causes neoplastic transition and epithelial-mesenchymal plasticity in human cellsSemantic proximity Read

Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast CancerSemantic proximity Read

Single-cell analysis reveals inter- and intratumour heterogeneity in metastatic breast cancerSemantic proximity Read

Single-Cell and Spatial Profiling of Tumor Microenvironment Heterogeneity in Human OsteosarcomasSemantic proximity Read

A single-cell and spatially resolved atlas of human osteosarcomasSemantic proximity Read

Evolving concepts of tumor heterogeneitySemantic proximity Read

Tumor heterogeneity: preclinical models, emerging technologies, and future applicationsSemantic proximity Read

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.Semantic proximity Read

Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcomaSemantic proximity Read