Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis

Abstract excerpt

Cigarette smoke (CS) has been consistently demonstrated to be an environmental risk factor for amyotrophic lateral sclerosis (ALS), although the molecular pathogenic mechanisms involved are yet to be elucidated. Here, we propose different mechanisms by which CS exposure can cause sporadic ALS pathogenesis. Oxidative stress and neuroinflammation are widely implicated in ALS pathogenesis, with blood–spinal cord barr...

Topics

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• Amyotrophic Lateral Sclerosis Research
• Neurogenetic and Muscular Disorders Research
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

febfd8e5-9860-5e6d-8900-32e2c2f69db0

DOI

10.3390/neurosci2020008