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Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis

5 Oct 2024

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is linked to ageing and genetic and environmental risk factors, yet underlying mechanisms are incompletely understood. We aimed to evaluate epigenetic age acceleration (EAA), i.e., DNA methylation (DNAm) age acceleration, and its association with ALS case status and survival. METHODS: In this study, we included 428 ALS and 288 control samples collected between 2011...

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PMID: 39369616
DOI: 10.1016/j.ebiom.2024.105383

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