Article
Associations between lifestyle and amyotrophic lateral sclerosis stratified by C9orf72 genotype: a longitudinal, population-based, case-control study.
The Lancet. Neurology - 1 May 2021
Westeneng Henk-Jan, van Veenhuijzen Kevin, van der Spek Rick A, Peters Susan, Visser Anne E, van Rheenen Wouter, Veldink Jan H, van den Berg Leonard H
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is considered to be caused by both genetic and environmental factors. The causal cascade is, however, not known. We aimed to assess lifestyle during the presymptomatic phase of ALS, stratified by C9orf72 mutation, and examine evidence supporting causality of lifestyle factors. METHODS: This study was a longitudinal, population-based, case-control study that used...
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