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Article

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era.

Nature reviews. Neurology - 1 May 2015

Paez-Colasante Ximena, Figueroa-Romero Claudia, Sakowski Stacey A, Goutman Stephen A, Feldman Eva L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neurons, which results in weakness and atrophy of voluntary skeletal muscles. Treatments do not modify the disease trajectory effectively, and only modestly improve survival. A complex interaction between genes, environmental exposure and impaired molecular pathways contributes to pathology in patients with ALS. Epigenetic...

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Identifiers

PMID: 25896087
DOI: 10.1038/nrneurol.2015.57

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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