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Article

Molecular hallmarks of ageing in amyotrophic lateral sclerosis

2 Mar 2024

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing disorder affecting motor neurons in the brain, brainstem, and spinal cord. Unfortunately, there are few effective treatments, thus there remains a critical need to find novel interventions that can mitigate against its effects. Whilst the aetiology of ALS remains unclear, ageing is the major risk factor. Ageing is a...

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PMID: 38430277
DOI: 10.1007/s00018-024-05164-9

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