Article
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis.
The Lancet. Neurology - 1 May 2022
Goutman Stephen A, Hardiman Orla, Al-Chalabi Ammar, Chió Adriano, Savelieff Masha G, Kiernan Matthew C, Feldman Eva L
Abstract excerpt
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly gradually. Recent advances in genetic technology have led to the rapid identification of multiple new genes associated with the disease, and to a new understanding of oligogenic and polygenic disease risk. The overlap of genes...
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