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Article

The amyotrophic lateral sclerosis exposome: recent advances and future directions.

Nature reviews. Neurology - 1 Oct 2023

Goutman Stephen A, Savelieff Masha G, Jang Dae-Gyu, Hur Junguk, Feldman Eva L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with typical survival of only 2-5 years from diagnosis. The causes of ALS are multifactorial: known genetic mutations account for only around 70% of cases of familial ALS and 15% of sporadic cases, and heritability estimates range from 8% to 61%, indicating additional causes beyond genetics. Consequently, interest has grown in...

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Identifiers

PMID: 37709948
DOI: 10.1038/s41582-023-00867-2
PMCID: PMC11027963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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