Article

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

2023-10-13

Abstract excerpt

The human GABA transporter (GAT1) is a membrane transporter that mediates the reuptake of the neurotransmitter GABA from the synaptic cleft into neurons and glial cells. Dysregulation of the transport cycle has been associated with epilepsy and neuropsychiatric disorders, highlighting the crucial role of the transporter in maintaining homeostasis of brain GABA levels. GAT1 is a secondary active transporter that co...

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Literature Corpus work: fea6aa49-5696-5954-b809-cc7c4c8c0794
DOI: 10.1101/2023.10.10.561652

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