Article

Class A GPCRs use the membrane potential to increase their sensitivity and selectivity

2019-03-23

Abstract excerpt

The human genome contains about 700 genes of G protein-coupled receptors (GPCRs) of class A; these seven-helical membrane proteins are the targets of almost half of all known drugs. In the middle of the helix bundle, crystal structures revealed a highly conserved sodium-binding site, which is connected with the extracellular side by a water-filled tunnel. Sodium ions are observed in GPCRs crystallized in their ina...

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Literature Corpus work: ad9ccef4-c2de-59d5-a1ff-4497091f8e93
DOI: 10.1101/587576

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