Article

Structural basis for selective inhibition of human GABA transporter GAT3

2025-03-28

Abstract excerpt

The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy for elevating extracellular GABA levels for the treatment of neurological disorders including epilepsy. However, few potent and selective GAT3 inhibitors have been developed, and their mechanisms of inhibition remain p...

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Literature Corpus work: f7a1420c-9bf8-5f3b-8f71-b6b8cab54a7a
DOI: 10.1101/2025.03.27.645797

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