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Article

Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010

Larsson H Peter, Wang Xiaoyu, Lev Bogdan, Baconguis Isabelle, Caplan David A, Vyleta Nicholas P, Koch Hans P, Diez-Sampedro Ana, Noskov Sergei Y

Abstract excerpt

Excitatory amino acid transporters (EAATs) remove glutamate from synapses. They maintain an efficient synaptic transmission and prevent glutamate from reaching neurotoxic levels. Glutamate transporters couple the uptake of one glutamate to the cotransport of three sodium ions and one proton and the countertransport of one potassium ion. The molecular mechanism for this coupled uptake of glutamate and its co- and...

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PMID: 20634426
DOI: 10.1073/pnas.1006289107
PMCID: PMC2922246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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