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Article

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel.

The Journal of general physiology - 4 May 2026

Maeda Yuki K, Kojima Kentaro, Nakamura Tomoe Y, Nakatsu Toru, Irie Katsumasa

Abstract excerpt

Voltage-gated sodium channels (Navs) selectively conduct Na+ to generate action potentials. Na+ permeates Navs with significantly higher efficiency than many other cations, but Li+ can also permeate Navs to an extent comparable with Na+. Li+ in the blood is known to enter cells via Navs and to have a beneficial effect on various neuropathies. However, the molecular basis of the high Li+ selectivity of Navs was...

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Identifiers

PMID: 41711638
DOI: 10.1085/jgp.202513855
PMCID: PMC12919392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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