Article

Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters

2023-12-04

Abstract excerpt

Secondary active membrane transporters harness the energy of ion gradients to concentrate their substrates. Homologous transporters evolved to couple transport to different ions in response to changing environments and needs. The bases of such diversification, and thus principles of ion coupling, are unexplored. Employing phylogenetics and ancestral protein reconstruction, we investigated sodium-coupled transport...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a08468be-92f0-58ca-bf16-a322c5f4c097
DOI: 10.1101/2023.12.03.569786

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary analysis reveals the origin of sodium coupling in glutamate transportersDOI 10.1101/2023.12.03.569786Read

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformationSemantic proximity Read

Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.Semantic proximity Read

Mechanisms of anion conduction by coupled glutamate transporters.Semantic proximity Read

Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.Semantic proximity Read

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.Semantic proximity Read

Structure and function of sodium-coupled GABA and glutamate transporters.Semantic proximity Read

The uncoupled chloride conductance of a bacterial glutamate transporter homolog.Semantic proximity Read

Glutamate transporters have a chloride channel with two hydrophobic gates.Semantic proximity Read

Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporter.Semantic proximity Read

Class A GPCRs use the membrane potential to increase their sensitivity and selectivitySemantic proximity Read

Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1.Semantic proximity Read

Structure of a glutamate transporter homologue from Pyrococcus horikoshii.Semantic proximity Read