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Article

Ion binding and permeation at the GABA transporter GAT1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 1996

Mager S, Kleinberger-Doron N, Keshet G I, Davidson N, Kanner B I, Lester H A

Abstract excerpt

This study addresses the binding of ions and the permeation of substrates during function of the GABA transporter GAT1. GAT1 was expressed in Xenopus oocytes and studied electrophysiologically as well as with [3H]GABA flux; GAT1 was also expressed in mammalian cells and studied with [3H]GABA and [3H]tiagabine binding. Voltage jumps, Na+ and Cl- concentration jumps, and exposure to high-affinity blockers...

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Identifiers

PMID: 8757253
PMCID: PMC6578888

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