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Article

Identification of specific susceptibility loci for the early-onset colorectal cancer.

Genome medicine - 3 Mar 2023

Wang Haoxue, Cai Yimin, Jin Meng, Huang Chao Qun, Ning Caibo, Niu Siyuan, Fan Linyun, Li Bin, Zhang Ming, Lu Zequn, Dong Xuesi, Luo Zilin, Zhong Rong, Li Heng, Zhu Ying, Miao Xiaoping, Yang Xiaojun, Chang Jiang, Li Ni, Tian Jianbo

Abstract excerpt

BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising rapidly, whereas the EOCRC genetic susceptibility remains incompletely investigated. Here, we aimed to systematically identify specific susceptible genetic variants for EOCRC. METHODS: Two parallel GWASs were conducted in 17,789 CRC cases (including 1490 EOCRC cases) and 19,951 healthy controls. A polygenic...

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Identifiers

PMID: 36869385
DOI: 10.1186/s13073-023-01163-w
PMCID: PMC9983269

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POLA2

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