Article
Assessment of a Polygenic Risk Score for Colorectal Cancer to Predict Risk of Lynch Syndrome Colorectal Cancer.
JNCI cancer spectrum - 1 Apr 2021
Jenkins Mark A, Buchanan Daniel D, Lai John, Makalic Enes, Dite Gillian S, Win Aung K, Clendenning Mark, Winship Ingrid M, Hayes Richard B, Huyghe Jeroen R, Peters Ulrike, Gallinger Steven, Marchand Loïc Le, Figueiredo Jane C, Pai Rish K, Newcomb Polly A, Church James M, Casey Graham, Hopper John L
Abstract excerpt
It was not known whether the polygenic risk scores (PRSs) that predict colorectal cancer could predict colorectal cancer for people with inherited pathogenic variants in DNA mismatch repair genes-people with Lynch syndrome. We tested a PRS comprising 107 established single-nucleotide polymorphisms associated with colorectal cancer in European populations for 826 European-descent carriers of pathogenic variants in...
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