Article

Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I

2018-04-24

Abstract excerpt

Most transcriptional activity of exponentially growing cells is carried out by the RNA Polymerase I (Pol I), which produces a ribosomal RNA (rRNA) precursor. In budding yeast, Pol I is a multimeric enzyme with 14 subunits. Among them, Rpa49 forms with Rpa34 a Pol I-specific heterodimer (homologous to PAF53/CAST heterodimer in human Pol I), which might be responsible for the specific functions of the Pol I. Previou...

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Literature Corpus work: fe65e5ab-da14-538b-a654-8f4cd82476da
DOI: 10.1101/307199

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